开心彩票网

中药经皮给药治疗乳腺增生病研究概述

时间:2018-4-29 分享到:

SONGAILI  SHANDONGZHONGYIYAODAXUEFUSHUYIYUAN(250012)

LIXIANGQI  SHANDONGZHONGYIYAODAXUE2003JIBOSHIYANJIUSHENG(250014)

ZHONGYAOJINGPIJIYAOSHIJIANGYAOWUZHIJIESHIYUHUANCHUHUOXIANGYINGXUEWEI,TONGGUOTOUPIXISHOU,YAOLIZHIDABINGSUO,FAHUIYAOXIAO,DADAOXIANGYINGZHILIAOMUDE。JINGPIJIYAOXITONGTTSKEYIBUJINGGANZANGSHOUGUOXIAOYINGHEWEICHANGDAODEPOHUAI,BUSHOUWEICHANGXIAOHUAMEI、XIAOHUAYE、PHZHIDENGZHUDUOYINSUYINGXIANG,KEYITIGAOSHENGWULIYONGDU,TIGONGKEYUDINGDEHEJIAOZHANGDEZUOYONGSHIJIAN,JIANGDIYAOWUDUXINGHEFUZUOYONG,WEICHIWENDINGERCHIJIUDEXUEYAONONGDU,TIGAOLIAOXIAO,JIANSHAOJIYAOCISHUDENG。TEBIESHIRUFANGJIBING,GENGSHIHEJINGPIJIYAO,YINQISHITIBIAOQIGUAN,YOULIYUYAOWUDEXISHOU。TOUPIJIYAOZHIJIYIQIFUZUOYONGXIAO、ZHANGXIAOFANGBIANDENGDUTEYOUSHIXIYINZHONGDUOGUONEIWAIZHIJIXUEZHUANJIA,BINGCHENGGUODANGJINGUOJIZHIYAOXUEDEYANJIUREDIANZHIYI。

1. 中药经皮给药吸收机理

1.1中药经皮给药与中药透皮吸收机理研究的历史

JINGPIJIYAOSHIYIZHONGGULAODEJIYAOFANGSHI,ZAOZAIGONGYUANERSHIJIWOGUOYIDIAN “NEIJING.SUWEN”ZHONGJIUYOUJIZAI,SONGDAI《TAIPINGHUIMINHEJIJUFANG》YIYOUKEYONGYUJUBUZHILIAOHUOTOUPIXISHOUDEGAOYAO。QINGDAIMINGYIXULINGTAICENGWEI“YONGGAOTIEZHI、BISAIQIQI,SHIYAOXINGCONGMAOKONGERRUQICOULI,TONGJINGGUANLUO,HUOTIERCHUZHI,HUOGONGERSANZHI,JIAOZHIFUYAOYOUYOULI,CIZHIMIAOZHIFAYE”,ZHEIYIDUANLUNSHUMINGQUECHANSHULEPIFUXISHOUJILI。QINGDAIWAIZHIDASHIWUSHIJIZAI《LIYUPIANWEN》ZHONGZHICHU:“WAIZHENGYONGYAOJINEIZHENGZHILI,WAIZHENGZHIYAOJINEIZHENGZHIYAO,SUOYIZHE,FAER”,YISISHI“YONGYAOSHIXIANGDENGXIANGTONGDE,ZHISHIJIYAOFANGFAHEJIYAOTUJINGSHIBUTONGERYI”ZHONGYAOJINGPIJIYAOFANGSHIZHONGDUO,《GUJINZHONGYAOWAIZHIZHENCHUAN》YISHUSHOUZAIYOUTIE、FU、TU、XI、YU、LIN、JINZI、WEI、GUO、XUN、YUN、YAOYA、LIZIDAORU、YAOCILIAOFADENGZHONGYIWAIZHI50YUFA。YOUYUKEXUEDEJINBU,XIANDAI“JINGPIJIYAO“YUANYUANTUPOLECHUANTONGJIEXIAN。SHIFANGXIZHICONGJIZHIZHONGTUOLICHULAIBINGKUOSANDAOPIFUHUOZHANMOBIAOMIANSHANG;CHUANTOUXIZHIYAOWUTONGGUOBIAOPIJINRUZHENPI、PIXIAZUZHI,ZHUYAODUIJUBUZUZHIQIZUOYONG;XISHOUXIZHIYAOWUTONGGUOPIFUZHANMOHUOZHANMOJICHUHUOLINBAGUANJINRURENTIXUNHUANERCHANSHENGQUANSHENZUOYONG。

1.2经络传导

JINGLUOSHIRENTIZUZHIDEZHONGYAOZUCHENGBUFEN,SHIGOUTONGBIAOLISHANGXIADEYIGEDUTEXITONG,WAIYUJIFUCOULIXIANGLIAN,NEIYUWUZANGLIUFUXIANGJIE,QIDAOYUNXINGQIXUE,RUYANGZANGFU、ZUZHI,CHUANDAOGANYINGHEDIAOHEYINYANGDEZUOYONG,YONGZHONGYAOWAIFUYOUGUANXUEWEI,JIYOUXUEWEICIJIZUOYONGYOUYOUJINGLUOCHUANDAOZUOYONG,SHIYAOWUCHONGFENFAHUIQIGONGXIAO。RUFANGWEIYUXIONGZHONG,JINGJINGLUOJIAOHUIZHICHU,QIZHONGZUYANGMINGWEIJINGGUANRUZHONG,ZUJUEYINGANJINGSHANGGUANGE,BUXIONGLEI,RAORUTOU;ZUSHAOYINSHENJINGCONGSHENSHANGGUANGANGE,RUFEIZHONG,QIZHIMAIRUXIONGZHONG;ZUSHAOYINPIJING,SHANGGE,JINGYURUWAICE,;RENMAIXINGYULIANGRUZHIJIAN;CHONGMAIXIEQISHANGXING,ZHIXIONGZHONGERSAN。YINCI,RUFANGBEICHENGWEI“ZONGMAIZHISUO“。ERGANSHENLIANGJINGYURUFANGGUANXIMIQIE,QICICHONGRENERMAI,GANSHENBUZU,CHONGRENSHIDIAOYINQIRUPIZHONGYAOYUANYIN。

1.3皮肤透入

开心彩票网ZHONGYAOJINGPIJIYAOFANGSHIHENDUO,YIBANYAOWURUONENGTONGGUOBIAOPIDOURONGYICONGZHENPIXISHOUDAORENTI,PIFUJIYAOYOUDIAN:BIMIANWEICHANGDAOYUGANZANGSUNHAI,TONGSHIBIMIANLEWEICHANGDAOYUGANZANGDUIYAOWUDEPOHUAI,CONGERTIGAOYAOWULIYONGDU。YAOWUTOUPIXISHOUJIUSHIYAOWUYUJUBUPIFUJIECHU,CHUANGUOJIAOZHICENG,KUOSANTOUGUOBIAOPI、JIAOZHICENGXIBAOJIANXI,MAONANG、PIZHIXIANJIHANXIANDENGTUJINGSHIXIAN。SUIRANPIFUXIBAOMOSHILEIZHIXINGDE,FEIJIXINGJIAOQIANG,YIBANZHIRONGXINGYAOWUJIAOSHUIRONGXINGYAOWUGENGRONGYICHUANTOUPIFU,DANQIZUZHIYEQUESHIJIXINGDE。YINCI,JIYOUYIDINGZHIRONGXINGYOUYOUSHIDANGSHUIRONGXINGYAOWU,CHUANTOUZUOYONGZUIQIANG。CIWAIXUANZERUJIXINGJIZHI,TIANJIABIAOMIANHUOHUAJIJICUSHENJI,LIYONGLIZIDIANSHENJICHAOSHENGFADENG,YENENGCUJINYAOWUTOUPIXISHOU。TOUPIXISHOUDESANDATEDIAN:YAOWUBUSHOUGANZANGHEWEICHANGDAODE“SHOUGUOXIAOYING”YINGXIANG,YAOWULIYONGLVGAO,JIANXIAODUIWEICHANG、GANZANGSUNHAI,BIMIANYAOWUZAIGANZANGHUOWEICHANGDAOJIANGJIEHUOSHIHUO,KEANZHAOXUYAODESULVJIANGYAOWUTOUPISHURUTINEI,XUEYAONONGDUBAOCHIHENGDING。TOUPIXISHOUZHIJISHIYIZHONGXINXINGDEKONGZHISHIFANGXITONG,JUYOUJIYAOFANGBIAN,WUWEICHANGDAOCIJIHEGANZANGSHOUGUOXIAOYING,XUEYAONONGDUPINGWENDENGTEDIAN,SHENSHOUHUANZHEHUANYING,RUXIANZENGSHENGBINGDEJINGPIJIYAOZHILIAO,YAOWUTOUPIXISHOUKETONGGUORUFANGPIXIA、RUYUNXIAN、MAONANG、PIZHIXIANJIHANXIANLINBAGUANMANYANZHIXIANYEJIANHEXIAOYEJIANDENGTUJINGSHIXIAN。

2. 经乳房透皮吸收给药的生理解剖基础

2.1乳房的解剖基础

开心彩票网CHENGNIANFUNVDERUFANGWEIYUXIONGQIANBI,QIJIDIBUSHANGYUANPINGDI2HUOZHE3LEI,XIAYUANPINGDILIULEIHUOZHEDIQILEI,NEICEKEDAXIONGGU,WAICEYUANJIEJINYEZHONGXIAN,RUFANGWEIXINGZHENGQIGUAN,RUXIANWEIFUGUANPAOZHUANGXIANTI,RUFANGYOURUXIANJIJIEDIZUZHIGOUCHENG,RUXIANYOURUXIANGUANHEXIANXIAOYEZUCHENG。RUXIANBEIFUYOUZHIFANGDEJIEDIZUZHIFENGECHENG15-20GENANGZHUANGYE,CHENGWEIRUXIANYE。RUXIANYEYOUBEIZHIMIJIEDIZUZHIFENWEIDAXIAOBUTONGDERUOGANGEXIAOYE,XIAOYEZHONGYOUXIEZHANGXINGXIAOGUANJIXIANPAOGUAN,GUANZHOUWEIYOUXIAODENANGZHUANGPENGDAJIXIANPAO,XIANPAOLIANTONGXIAODAOGUAN,HOUZHEJICHENGDADAOGUAN,ZUIHOUHUICHENGYITIAOGENGDADEDAOGUAN,CHENGWEISHURUGUAN。

2.2乳房透皮吸收给药是药物到达腺叶的可能途径。

LINBATUJING:RUFANGDELINBAGUANWANGFENWEIQIANSHENLIANGZU,BICIZHIJIANYOUGUANGFANWENHE。RUXIANQIANLINBAGUANFENBURUFANGDEPINEIHEPIXIAZUZHI,LINBAGUANWUBANMO,ZAIRUYUNXINGCHENGRUYUNXIALINBAGUANWANG,ZHURUSHENLINBAGUANHUOXIONGJILINBAJIE,SHENBULINBAGUANWANGGUANGFANFENBUZAIRUXIANXIAOYEZHOUWEIDEJIANXIHESHURUGUANBINEI。JINGRUFANGTOUPIXISHOUDEYAOWUKEJINGCITUJINGDAODAXIANYE,FAHUIZHILIAOZUOYONG。GUOWAIYANJIUBIAOMING:RUXIANPIFUDEQIANBIAOLINBAWANGYURUXIANSHIZHIDELINBAWANGZAIRUYUNXIAYOUFENGFUDEWENHE。RUYUNXIADEMAOXILINBAGUANZHIJING10-50ym,GUANBIYOUDANCENGSHANGPIXIBAOHEFEILIANXUXINGFENBUDEJIDIMOGOUCHENG,CHENGDIEWAZHUANGPAILIEDESHANGPIXIBAOYOU10-25nm,YUNXUYIXIEXIAOKELIJINRULINBAGUAN,DAKELIKETONGGUOBAOYINFANGSHIJINRULINBAGUAN。ZHEISHIYAOWUJINGPIDAORUXUANZEYOUZHIDAOYIYI。

XUEYUNTUJING:NVXINGRUFANGDEPIXIAZHIFANGFENGFU,ERRUYUNHUANPIFUZUIBO,PIXIAZHIFANGCENGSHUSONG,BIANYUYAOWUTOUPIXISHOU。RUYUNQUDEXUEGONGYOUSANZUXIXIAODEXUEGUANWANGZUCHENG,JIRUYUNZHENPIXIAXUEGUANWANG、RUXIANDAOGUANZHOUWEIHERUTOUXIAFANGDEMAOXIXUEGUANWANG,RUYUNZHOUWEIDEDONGMAIHUANSHANGDEFUSHEZHUANGFENZHI,ZHEISANZUXUEGUANXIANGHUWENHE。RUFANGJINGMAIFENQIANSHENLIANGZU。QIANZUJINGMAIJINTIEPIXIA;SHENZUJINGMAIYUQITONGMINGDONGMAIBANXING。QIANSHENJINGMAIDOUHUIRUYEJINGMAIHEXIONGKUONEIJINGMAI。WAIYUANXINGYAOWUKETONGGUOCITUJINGDAODARUXIANYE,FAHUIZHILIAOZUOYONG。WAIYUANXINGYAOWUKETONGGUOZHEIXIETUJINGCHONGFENSHENTOUZHIRUXIANXIAOYEZHOUWEI,FAHUILIANGHAODEZHILIAOZUOYONG。

3. 乳腺增生病经皮给药方式

开心彩票网RUXIANZENGSHENGBINGSHIPUWAIKECHANGJIANJIBING,GUONEIWAIDUOCAIYONGTOUPIJIYAODEFANGSHI,ZHEIYANGKEBIMIANKOUFUJIYAODUIGANZANGDESHOUGUOXIAOYINGJIDUIWEICHANGDAODEDUFUZUOYONG,JINGPIJIYAODEFANGSHIDUOZHONGDUOYANG,FENSHURUXIA:

3.1中药煎剂外洗、外敷

ZHONGYAOWAIYONGYOUZHEDUTEDEYOUSHIHELIAOXIAO,YAOWUZHIJIEZUOYONGYUBINGBIANBUWEI,TONGGUOYAOWUTOUPIZUOYONG,XINGQIHUOXUE,HUAYUSANJIE,CONGERJIECHUZHENGZHUANG。

3.2中药贴服

开心彩票网ZHONGYAOTIEFUSHIJIANGCHUANTONGZHONGYAO,CAIYONGXIANDAIZHIJIDEFANGFAZHICHENGWAIYONGYAO,LINCHUANGYINGYONGFANGBIAN。

3.3中药穴位贴服、注射

XIANDAIYIXUEYANJIUFAXIAN,JINGXUEDUIYAOWUJUYOUWAIMINXINGHEFANGDAXIAOYING,JINGLUOXITONGSHIDIDIANZUYUNXINGTONGLU,YINCI,YAOWUTIEFUYUTESHUJINGXUE、XUNSUZAIXIANGYINGZUZHIQIGUANCHANSHENGJIAOQIANGYAOLIZUOYONG,QIDAODANXIANGHUOSHUANGXIANGDIAOJIEZUOYONG。

3.4中药外敷配合物理疗法

JINGPIJIYAODEYAOWUTOUPIJIYAOXISHOUKETONGGUOWANZHENGDEBIAOPI、JIAOZHICENGXIBAOJIANXI、MAONANG、PIZHIXIANJIHANXIANDENGTUJINGSHIXIAN。HAIKEYITONGGUOXUANZEPIFUJIAOZHICENGBO、MAOKONGDUODEBUWEIHUOZHESHIDANGXUEWEI、ZENGJIAPIFUWENDU,ZENGJIAPIFUJIAOZHICENGDESHUIHEZUOYONG,XUANZERUJIXINGJIZHI,TIANJIABIAOMIANHUOXINGJIJICUSHENJI,LIYONGLIZIDIANSHENJICHAOSHENGFAJINXINGYAOWUTOURUDENG,CUJINYAOWUTOUPIXISHOU。MEIRILIANGCI,2ZHOUWEIYIGELIAOCHENG,ZHILIAOZU30LIZHIYU14LI,HAOZHUAN13LI,WEIYU3LI,DUIZHAOZUZHIYU8LI,HAOZHUAN10LI,WEIYU12LI,LIANGZUDEZHILIAOJIEGUOJINGRiditFENXI,u=2.28 PXIAOYU0.05,SHUOMINGZHILIAOZULIAOXIAOYOUYUDUIZHAOZU。

3.5中药药物乳罩

开心彩票网ZHONGYAOYAOWURUZHAOSHIZHILIAORUXIANZENGSHENGJIBINGDEYOUXIAOFANGFA,PEIDAIFANGBIAN,ZUOYONGCHIJIU。GAOMEIRONGYONGCHAIHU、MEIYAO、KUNBU、DANGGUI、SHENGMULI、YINYANGHUO、CISHI、BINGPIANZHICHENGYAOCIRUZHAO,MEIZHOUGENGHUANYICI,YIYUEYILIAOCHENG。ZHILIAOZENGSHENGBING96LI,ZHIYU26LI,XIANXIAO32LI,YOUXIAO30LI,WUXIAO8LI。

4. 讨论

RUXIANZENGSHENGBINGSHINVXINGCHANGJIANJIBING,BINGCHENGZHANG,FUFALVGAO,BINGJUYOUAIBIANWEIXIAN,WOGUOXIANYIJINGJIANGBENBINGLIEWEIAIQIANQIBINGBIAN。ZHENGQUEZHILIAOKEYIZHIYU,YIBANYUHOULIANGHAO。RUOZHILIAOBUDANG,HUOFANFUFAZUO,BUFENRUXIANZENGSHENGBINGKEYANBIANWEIFEIDIANXINGZENGSHENG,FAZHANWEIRUXIANAI,YINERYINGYUZUGOUZHONGSHI。RUXIANZENGSHENGBINGDEJINGPIJIYAOZHILIAO,SHIYAOWUTOUGUOTOUPIXISHOUERQIZUOYONGDEYIZHONGWAIZHIFANGFA,TABUDANKEBIMIANGANZANGSHOUGUOXIAOYING,ERQIEJIANGDIHUANZHEZHIJIANDEGETIJIANJIGETINEICHAYI,WEICHIWENDINGDEXUEYAONONGDU。JINGPIJIYAOKETIGONGYIZHONGZHANGQIDEJIYAOFANGFA,YEKESUISHITINGZHIJIYAO,SHIYIZHONGFANGBIANDEJIYAOFANGSHI。

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