开心彩票网

低频超声导药仪靶向药物治疗颈部淋巴结结核的临床观察

时间:2018-4-29 分享到:

【摘要】  目的 观察化疗联合低频超声导药仪靶向药物治疗颈部淋巴结结核的疗效。方法 61 例颈部淋巴结核患者随机分为治疗组和对照组,治疗组31例,对照组30例。治疗组采用抗结核药物化疗联合低频超声导药仪治疗,对照组采用单纯抗结核药物治疗,2组均采用超声影像结果进行临床疗效评估。结果 治疗1个月及6个月后治疗组有效率明显高于对照组(P<0.05)。结论 化疗联合低频超声导药仪靶向药物治疗颈部结节型和浸润型淋巴结核疗效确切,安全、高效,值得推广。

【关键词】 开心彩票网 分枝杆菌,淋巴结核;超声电导议;药物治疗;治疗结果

开心彩票网LINBAJIEHESHIFEIWAIJIEHEZHONGZUICHANGJIANDELEIXING,ZHANFEIWAIJIEHEDE30%~40%,QIZHONGJINGBULINBAJIEJIEHEYUEZHAN90%[1]。TONGCHANGCAIYONGDANCHUNKANGJIEHEZHILIAOHUOLIANHEJUBUZHUSHE、WAIKESHOUSHUQIECHUDENGFANGFAZHILIAOJINGBULINBAJIEHE。WOYUAN2009NIAN3ZHI10YUESHOUZHIJINGBULINBAJIEJIEHEBINGHUANZHE61LI,CAIYONGDIPINCHAOSHENGDAOYAOYIJUBUTOUYAOLIANHEKANGJIEHEYAOWUZHILIAO,SHOUDAOMANYIDEZHILIAOXIAOGUO,BAOGAORUXIA。

  1 资料与方法

  1.1 一般资料

61LIZHONG,NAN19LI,NV42LI,NANNVBILI1∶2.2;NIANLING16~45SUI,PINGJUNNIANLING35SUI;JINGBXINGCHAOSHENG(BCHAO)YINDAOXIALINBAJIECHUANCIHUOJIAN,BINGLIZHENGSHIWEILINBAJIEJIEHEDE52LI,9LIHUANZHENONGZHITUPIANKANGSUANRANSEYANGXING。YOUCEJINGBU25LI,ZUOCEJINGBU19LI,SHUANGCEJINGBU17LI;DANGELINBAJIESHOULEIZHE12LI(19.7%),2GELINBAJIESHOULEIZHE17LI(27.9%),DUOGELINBAJIESHOULEIZHE32LI(52.4%);JINGBUBINGZAOPOKUI13LI,BINGZAOYIXINGCHENGNONGZHONG18LI;HEBINGJIFAXINGFEIJIEHEZHE27LI(44.3%),HEBINGJIEHEXINGXIONGMOYANZHE5LI(8.2%)。61LISUIJIFENWEIDUIZHAOZUHEZHILIAOZU。ZHILIAOZU31LI,WEIKANGJIEHEYAOWULIANHEDIPINCHAOSHENGDAOYAOYIBAXIANGYAOWUZHILIAO;QIZHONGJIEJIEXING10LI,NONGZHONGXING9LI,KUIYANGXING7LI,JINRUNXING5LI;DUIZHAOZU30LI,WEIDANCHUNKANGJIEHEYAOWUZHILIAO。QIZHONGJIEJIEXING12LI,NONGZHONGXING9LI,KUIYANGXING6LI,JINRUNXING3LI。2ZUYIBANZILIAOYOUJUNHENGXING。

  1.2 治疗方法

开心彩票网KANGJIEHEZHILIAOFANGAN:2ZUJUNSHIYONGYOUYIYANJING(H)、LIFUPING(R)、BIQINXIANAN(Z)、YIANDINGCHUN(E)HUOLIANMEISU(S)ZUCHENGDE3HRZE(S)/9HREFANGANHUALIAO,QIANGHUAQIZHISHAO1GEYUEZAIYIYUANNEIJIESHOUZHILIAO。ZHILIAOZUTONGSHIDIPINCHAOSHENGDAOYAOYIJIZHUANYONGDENINGJIAOTIEPIANJINXINGBAXIANGYAOWUZHILIAO,MEIGETIEPIANHANYIYANJING0.05 gHELIUSUANAMIKAXING0.1 g,ZAIZENGDADELINBAJIEZUIMINGXIANDEBUWEIQINGJIEPIFUHOU,TIESHANGANZHUANGHAODAIYAOOUHENINGJIAOTIEPIAN,LIANJIEBINGGUDINGHAOZHILIAOTOU,DIANYA220 V,YOUXIAOCHAOSHENGSHUCHUGONGLV1.5 W,2CI/d,20 min/CI,15 dWEI1LIAOCHENG。

  1.3 评定方法

2ZUZHILIAOQIANJIQIANGHUAQI3GEYUE,MEIBANYUEJINXING1CIJINGBULINBAJIECHAOSHENG,ZHIHOUMEIGEYUEJINXING1CIJINGBULINBAJIECHAOSHENG,JILULINBAJIEBIANHUAQINGKUANG。

  1.4 疗效标准

开心彩票网CHAOSHENGJIEGUOXIANSHI:LINBAJIEXIAOSHIWEIQUANYU,SUOXIAO>1/2WEIXIANXIAO,<1/2WEIYOUXIAO,WUBIANHUA、ZENGDAWEIWUXIAO。ZONGYOUXIAO=XIANXIAO+YOUXIAO。

  1.5 统计学分析

开心彩票网JISHUZILIAOCAIYONGχ2JIANYAN,P<0.05WEICHAYIYOUTONGJIXUEYIYI。

  2 结果

2ZUZHILIAO1、6GEYUEYOUXIAOLVCHAYIYOUTONGJIXUEYIYI(P<0.05)。JIANBIAO1、2。BIAO1 2ZUZHILIAO1GEYUELIAOXIAOBIJIAOLIBIAO2 2ZUZHILIAO6GEYUELIAOXIAOBIJIAOLI

  3 讨论

JINGLINBAJIEJIEHEWEIZUICHANGJIANQIANBIAOLINBAJIEJIEHEBING,QINGSHAONIANHAOFA,NVXINGDUOJIAN,HUANZHEDUOYIJINGBUZHONGKUAIJIUZHEN,SHAOSHUHUANZHEKEYOUFARE、FALIDENGQUANSHENZHENGZHUANG。QIGANRANTUJINGYOUSANZHONG:(1)YOUPIFU、NIANMOJIEZHONGGANRAN,XINGCHENGKOUYANZONGHEZHENG,ZAIYOUYUANFABINGZAOZHIJIEJINGLINBAJIEBOSANZHIJINGBUXIANGYINGDELINBAJIEQUN;(2)LINBAJIEJIEHEBINGBIANDEZAIRAN;(3)XUEXINGBOSANZHIJINGBULINBAJIE[2]。JIEHEXINGLINBAJIEYANDEBINGLIGAIBIANKEFEN4GEJIEDUAN:(1)LINBAZUZHIZENGSHENG、XINGCHENGJIEJIEHUOROUYAZHONG;(2)LINBAJIENEIBUGANLAOYANGYEHUAHUAISI;(3)LINBAJIEBAOMOPOHUAI,HUXIANGRONGHEHEBINGLINBAJIEZHOUWEIYAN;(4)GANLAOWUZHICHUANPOZHIZHOUWEIRUANZUZHIXINGCHENGLENGNONGZHONGHUODOUDAO。LINBAJIEJIEHEANBINGCHENGFAZHANFENWEISIXING:JIEJIEXING、JINRUNXING、NONGZHONGXING、KUIYANGXINGHUOKUIYANGLOUGUANXING[2]。

开心彩票网JINGBULINBAJIEJIEHEYIDANGEBUWEI、DANGELINBAJIESHOULEIWEIZUICHANGJIAN。YOUCEJUDUO,YUEZHAN68.5%,ZUOCEZHAN31.5%。FABINGNIANLINGYI20~49SUIDUOJIAN,NVXINGFABINGZHEDUOJIAN,NANNVBILIWEI1∶1.7。BENZUBINGLINANNVBILIWEI1∶2.2,DUOGELINBAJIESHOULEIZHAN52.46%[2]。

MUQIANDUILINBAJIEJIEHEDEZHILIAOYOUHENDUOFANGFA,QILIAOXIAOYECANCHABUQI。DANCHUNHUALIAO、JUBUFENGBIZHILIAO、HUALIAOLIANHEJUBUZHUSHEZHILIAO、ZHONGYIZHILIAOHESHOUSHUQIECHUZHILIAO。DANCHUNYINGYONGKANGJIEHEYAOWUHUALIAO,JIN70%DEBINGBIANKEYIZHIYU,QIEJINXIANYUYANZHENGXINGLINBAJIEHE,HEBENDUIZHAOZULIAOXIAOYIZHI。YOUBAODAODUIYUJIEJIEXINGHEJINRUNXINGLINBAJIEHECAIYONGYIYANJINGDENGJUBULINBAJIEFENGBILIAOFA,YOUYUXUYAOFANFUCHUANCIZHUSHEJIYAO,SUIKEYITIGAOLINBAJIEJIEHEDEZHIYULV,DANYIZAOCHENGZHENDAOHUNHEGANRAN,JIJINGLINBAJIEJIEHEDEZHILIAODAILAIKUNNAN。DUIYUJIEJIEXING、NONGZHONGXINGJINGHUALIAOHOURENGBUSUOXIAO,FANERZENGDAHUOZENGDUOZHEYINGZUOLINBAJIEZHAICHUSHUHUONONGZHONGQIEKAIYINLIU、BINGZAOQINGCHUSHOUSHU,JIZHONGYIDENG[3]DUI32LINONGZHONGXING、KUIYANGXINGLINBAJIEHEHE10LIJINGNEIKEZHILIAOFANERZENGDADEJIEJIEXINGLINBAJIEHECAIYONGSHOUSHUQINGCHUBINGZAOJISHUHOUYONGLIFUPINGFANSHILINSHABUJIERUZHILIAO,SHIQIANGNEIWUGANGEYANGWUHEJIEHEJUNCANYU,DADAOCHUANGMIANQINGJIE,CUJINYUHEDEMUDE,JINQIZHIYULVDADAO100%。JIYUSHANGSHUHUALIAOLIANHEJUBUZHUSHEZHILIAOKEYITIGAOJINGBULINBAJIEHEZHIYULVDEJINGYAN,WEILEBIMIANJUBUFANFUZHUSHEDAIJIHUANZHEDETONGKU,WOMENCAIYONGHUALIAOLIANHEDIPINCHAOSHENGDAOYAOYIBAXIANGYAOWUZHILIAOJINGBULINBAJIEJIEHE,QUDELEMANYIDELINCHUANGXIAOGUO。

DIPINCHAOSHENGDAOYAOYIJINGPIJIYAOJISHUSHIJINNIANGUOWAICHUXIANDEYIZHONGYAOWUSHENTOUDEXINFANGFA,SHIYIZHONG“WUCHUANGBAXIANGJIYAO”XINFANGFA。 CHAOSHENGBOKETONGGUOQIFUSHEYAHEKONGHUAXIAOYING,CUJINYAOWUJINGPIFUTOURUTINEI。TAKEGAIBIANXIBAOMOHEZUZHIMOZHIZHIJIEGOUDEPAILIESHUNXU,ZENGJIAPIFUHEZUZHIDETONGTOUXING,WEIYAOWUJINRUTINEITIGONGLEDONGNENG,KEYOUXIAODETIGAOYAOWUDETOUPISULV。BINGQIEZAISHENBUBINGBIANZUZHIXINGCHENGYAOWUGAONONGDUJUJI,BIKOUFUHEJINGMAIJIYAOFADENONGDUGAOJISHIBEISHENZHIBAIBEI[4],TIGAOLEYAOWUDELIYONGDU;ZAIZHEYONGCHAOSHENGBOJUBUTOURUYAOWUZHILIAOJINGLINBAJIEHEKEBIMIANQUANSHENYONGYAODEBULIANGFANYINGYONG,SHIDUICHUANTONGJIYAOGUANNIANDEZHONGDATUPO[5]。BENGUANCHAZHONGZHILIAOZUZAIJINGGUO1GEYUEDEZHUYUANZHILIAOHOU,YOUXIAOLVWEI93.5%,MINGXIANGAOYUDUIZHAOZU70.0%(P<0.05)。2ZU11LIZHILIAOSHIBAIDEBINGLI,2LIWEIZHILIAOZU,9LIWEIDUIZHAOZU,JUNWEINONGZHONGXINGLINBAJIEHE,LINGWAI7LINONGZHONGXINGHE13LIKUIYANGXINGLINBAJIEHE,JINGGUOJINGPICHAOSHENGTOUYAOZHILIAO,ZHOUBIANJINRUNXINGLINBAJIEMINGXIANSUOXIAO,BEILIERUYOUXIAOFANWEI。ZHILIAO6GEYUEHEZHILIAO1GEYUEDELIAOXIAOXIANGBI,YOUXIAOLVMEIYOUMINGXIANTIGAO,SUOYIJINGBULINBAJIEHEDEZHILIAOYINGQIANGDIAOZAOQIQIANGHUAWEIYI。DUINONGZHONGXINGHEKUIYANGXINGJINGBULINBAJIEHEYINGZAIQUANSHENKANGJIEHEYONGYAODETONGSHIJIJICAIYONGSHOUSHUZHILIAO,CAINENGQUDELIXIANGDELIAOXIAO。

开心彩票网HUALIAOLIANHEDIPINCHAOSHENGDAOYAOYIJINGPITOUYAOZHILIAOJINGBUJIEJIEXINGHEJINRUNXINGLINBAJIEHE,KEBIMIANLINBAJIEJUBUFANFUZHUSHEDETONGKU,YOUXIAOLVKEDA93.5%,LIAOXIAOQUEQIE,SHIYIZHONGANQUAN、GAOXIAODEJUBUZHILIAOFANGFA,ZHIDETUIGUANG。

【参考文献】

1 YANJINGHELANG,DAOWEIZHONGNANZHUBIAN.JIEHEBINGXUE.DI1BAN.HAERBIN:HEILONGJIANGSHENGCHUBANSHE,1987.342346.

2 MAYU,ZHULIZHEN,PANYUXUANZHUBIAN.JIEHEBING.DI1BAN.BEIJING:RENMINWEISHENGCHUBANSHE,2006.286293.

开心彩票网3 JIZHONGYI,LIUXIAODONG,LIYUECHUN,DENG.JINGBULINBAJIEJIEHEDEWAIKEJIERUZHILIAO.QINGDAOYIXUEZAZHI,2001,33:420421.

开心彩票网4 ZHUYUCUN.CUJINTOUPIJIYAODEWULIHESHENGHUAFANGFA.GUOWAIYIXUEYAOXUEFENCE,1993,12:15.

5 LIANGBINGWEN,LIANGWENQUAN,PINGQINENG,DENGZHUBIAN.JINGPIJIYAOZHIJI.DI1BAN.BEIJING:ZHONGGUOYIYAOCHUBANSHE,1992.180.

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